1.
Development of a DNA Diagnostic Probe
for the Detection of the Human Malarial
Parasite Plasmodium falciparum. V
S Francis, Kayyanathan, P Bhat, H
Srinivasa & G Padmanaban. Indian
Journal of Biochemistry & Biophysics,
1988: 25, 537-541.
2. Congo red mediated regulation of
membrane proteins of Shigella flexneri
2a.. K. Sankaran, Vasanthi Ramachandran,
Yerramilli V.B.K. Subrahmanyam, Shantha
Rajarathnam, Shanmugam Elango and
Raman K. Roy. Infection and Immunity,
1989: 57, 2364-2371.
3. Cloning and hyperexpression of
a gene encoding the heat-stable toxin
of Escherichia coli. (Recombinant
DNA; T7 and tac promoters; precursor
protein; nucleotide sequence; transcription;
processing). P. Dwarakanath, Sandhya
S. Visweswariah, Y.V.B.K. Subrahmanyam,
G. Shanthi, H.M. Jagannatha and T.S.
Balganesh. Gene, 1989: 81, 219-226.
4. Proteinase-like activity in the
cytotoxic factor produced by T cellsduring
dengue virus infection. M.Khanna,
U.C.Chaturvedi, B.R.Srinivasa, K.R.Swaminathan,
A.Mathur, Immunology, 1989: 67, 32-37.
5. Astra Research Centre, India- a
unique experiment in strategic collaboration.
Kumud Sampath. BioSpectra, 1990.
6. The primary structure of xylanase
from Thermoascus aurantiacus. B.R.
Srinivasa, K.R. Swaminathan, Chitra
Ganapathy, R.P. Roy, S.k. Murthy,
and P.J. Vithayathil.. Protein Sequence
& Data Analysis, 1991: 4, 15-20.
7. Strongly goal-oriented biomedical
research-Astra Research Centre India.
J. Ramachandran. Current Science,
1991: 60 No. 9&10, 533-536.
8. Identification of carbohydrate
structures as receptors for lacalised
adherent enteropathogenic Escherichia
coli. H.M. Jagannatha, Umender K.
Sharma, Tara Ramaseshan, A. Surolia
and T.S. Balaganesh. Microbial Pathogenesis,
1991: 11, 259-268.
9. Interaction of heat-stable enterotoxins
with human colonic (T84) cells: modulation
of the activation of guanylyl cyclase.
Sandhya S. Visweswariah, G. Shanthi
and T.S. Balganesh. Microbial Pathogenesis,
1992: 12, 209-218.
10. Neuroanatomy of Cysticercus Cellulosae
(Ceatode) as revealed by acetylcholinesterase
and nonspecific esterase histochemistry.
S. Vasantha, B.V. Ravi Kumar, S.D.
Roopashree, Sarala Das, and S.K. Shankar.
Parasitology Research, 1992: 78, 581-586.
11. Nucleic acids: the leading edge.
K. Ayyanathan. Current Science, 1992:
62 No. 6, 443-444.
12. Software Report: Molecular Graphics
Software-Mogra. N.V. Ramana and Indira
Ghosh, Computer & Graphics, 1993:
17 No. 4, 415-416.
13. Hysteresis And Statistical Errors
In Free Energy Perturbation L To D
Amino Acid Conversion. Olle Edholm
And Indira Ghosh, Molecular Simulation,
1993: 10 No. 2-6, 241-253.
14. Cloning of the triosephosphate
isomerase gene of Plasmodium falciparum
and expression in Escherichia coli.
Jamuna Ranie, Vidya P. Kumar and Hemalatha
Balaram, Molecular and Biochemical
Parasitology, 1993: 61, 159-170.
15. Restriction and modification systems:
Unrestricted frontiers. M. A. Mukund,
Current Science, 1993: 65 No. 7, 509-510.
16. Insights into Plasmid biology.
Umender K. Sharma, Current Science,
1993: 64 No. 5, 283-284.
17. The need for protection of intellectual
property rights for indian inventions
in biotechnology, S. Anand Kumar,
Journal of Scientific and Industrial
Research, 1993: 52, 304-307.
18. Designing a small
peptide toxin using Molecular Dynamics.
Indira Ghosh, Journal of Molecular
Graphics, 1993: 11, 62.
19. Structural characterization
of gelonin: Evidence for separate
antigenic and cytotoxic domains. M.R.
Sairam, B.R. Srinivasa and Jose Marcil,
1993: 31, 575-581.
20. Major histocompatibility complex
class I-binding peptides are recycled
to the cell surface after internalization.
U.M. Abdel Motal, X. Zhou, A. Joki,
A.R.Siddiqi, B.R.Srinivasa, K.Stenvall,
J.Dahmen, M.Jondal, European Journal
of Immunology, 1993: 23, 3224-3229.
21. Characterization and partial purification
of the human receptor for the heat-stable
enterotoxin. Sandhya S. Visweswariah,
Vasanthi Ramachandran, Surabhi Ramamohan,
Goutam Das And Janakiraman Ramachandran,
Europena Journal of Biochemistry,
1994: 219, 727-736.
22. Structure, function & therapeutic
potential of omega conopeptides: Novel
blockers of neuronal calcium channels.
J Ramachandran, Proc. Indian Acad.
Sci. (Chem. Sci.)., 1994: 106 No.
6, 1383-1387.
23. Analysis of E.coli promoter structures
using neural networks. Indu Mahadevan
and Indira Ghosh. Nucleic Acids Research,
1994: 22 No. 11, 2158-2165.
24. Molecular dynamics study of the
binding of phenylalanine stereoisomers
to thermolysin. Indira Ghosh and Olle
Edlholm, Biochemical Chemistry, 1994:
50, 237 - 248.
25. Cloning and sequence of a cDNA
encoding a novel hybrid proline-rich
protein associated with cytokinin-induced
haustoria formation in Cuscuta reflexa.
K. Subramaniam, Jamuna Ranie, B.R.
Srinivasa, Achyut M. Sinha and S.
Mahadevan, Gene, 1994: 141, 207-210.
26. Untapped Potetential, Kumud Sampath,
Pharmaceutical Visions, 1994: 2 No.
3.
27. Virulent Shigella codes for a
soluble apyrase: Identification, characterization
and cloning of the gene. Tishina Bhargava,
Santanu Datta, Vasanthi Ramachandran,
Ramesh Ramakrishnan, Raman K. Roy,
Krishnan Sankaran and Yerramilli V.
B. K. Subrahmanyam. Current Science,
1995: 68 No. 3, 293-300.
28. A Non-radioactive DNA diagnostic
procedure for the detection of malarial
infection: general application to
genome with repetitive sequences.
Kasirajan Ayyanathan and Santanu Datta.
Molecular and Cellular Probes, 1995:
9, 83-89.
29. Development of specific DNA probes
and their usage in the detection of
Plasmodium vivax infection in blood.
K. Ayyanathan, V.S.N.K. Francis, S.
Datta and G. Padmanaban, Molecular
and Cellular Probes, 1995: 9, 239-246.
30. Expression and Characterization
of the ponA (ORF I) Gene of Haemophilus
influenzae: Functional Complementation
in a Heterologous System. Umender
K. Sharma, P. Dwarakanath, Nabanita
Banerjee, C. Town, And T.S. Balganesh,
Journal Of Bacteriology, 1995: 177
No. 23, 6745-6750.
31. A CD4+ T cell line-secreted factor,
growth promoting for normal and leukemic
B cells identified as thioredixin.
Anders Rosen, Pia Lundman, Mats Carlsson,
Kasibhatla Bhavani, Bachally r. Srinivasa,
Gunila Kjellstrom, Kenneth Nelsson
and Arne Holmgren, 1995: 7, 625-633.
32. Alternative forms of the human
thioredoxin mRNA: identification and
characterization. Jayashree Hariharan,
Pratibha Hebbar, Jamuna Ranie, Philomena,
Achuyt Mohan Sinha and Santanu Datta,
Gene, 1996: 173, 265-270.
33. Identification and characterization
of a generic DNA probe capable of
detecting plasmodial infections in
blood. K. Ayyanathan and S. Datta,
Molecular and Cellular Probes, 1996:
10, 273-278.
34. Detection of virulent Shigella
and enteroinvasive Escherichia coli
by induction of the 43 kDa invasion
plasmid antigen, ipaC. Rita Shamlal,
Shantha Rajarathnam, Krishnan Shankaran,
Vasanthi Ramachandran, Yerramilli
V.B.K. Subrahmanyam, G. Balakrish
Nair, Ragini Macaden, Raman K. Roy,
FEMS Immunology and Medical Microbiology
1997: 17, 73-78.
35. Production of Recombinant Human
Bile Salt Stimulated Lipase and Its
Variant in Pichia pastoris. Anjali
V. Sahasrabudhe, Suresh M. Solapure,
Rajeev Khurana, Vepa Suryanarayan,
Sudha Ravishankar, Sunitha M. DeSousa,
and Goutam Das, Protein Expression
And Purification, 1998: 14, 425-433.
36. Developmental selection of var
gene expression in plasmodium falciparum.
Qijun Chen, Victor Fernandez, Annika
Sunstorm, Martha Schlichtherle, Santanu
Datta. Per Hagblom and Mats Wahlgren,
Nature, 1998: 394, 392-395.
37. Identification of Plasmodium falciparum
erythrocyte membrane protein 1 (PfEMP1)
as the rosetting ligand of the malaria
parasite P.falciparum. Quijn Chen,
Antonio Barragan, Victor Fernandez,
Annika Sundstorm, Martha Schlichtherle,
Anders Sahlen, Johan Carlson, Santanu
Datta, amd Wats Wahlgren, Journal
of Experimental Medicine, 1998: 187,
15-23.
38. Convergent synthesis of neoglycopeptides
by coupling of 2-bromoethyl glycosides
to cysteine and homocysteine residues
in T cell stimulating peptides. Marita
Bengtsson, Johan Broddefalk, Jan Dahmen,
Krister Henriksson, Jan Kihlberg,
Hans Lonn, B.R. Srinivasa and Kristina
Stenvall, 1998: 15, 223-231.
39. Mechanism-Based Inhibitors: Development
of a High Throughput Coupled Enzyme
Assay to Screen for Novel Antimalarials.
Jayashree Hariharan, Rajendra Rane,
Kasirajan Ayyanathan, Philomena, Vidya
Prasanna Kumar, Dwarakanath Prahlad
and Santanu Datta, Journal of Biomolecular
Screening, 1999: 4, 187-192.
40. Effect of mRNA secondary structure
in the regulation of gene expression:
Unfolding of stable loop causes the
expression of Taq polymerase E.Coli.
Mandyam Alasingachar Mukund, Tanmay
Banerjee, Indira Ghosh and Santanu
Datta, Current Science,1999: 76, 1486-1490.
41. Study of the interaction between
Bacterphage T4 asiA and Eschercia
Coli s70, using the Yeast two-hybrid
system: Neutralization of asiA Toxicity
to E.Coli cells by Coexpression of
a Turncated s70 fragment, Umnder K.
Sharma, Sudha Ravishankar, Radha Krishna
Shandil, P.V.K. Praveen, and T.S.
Balganesh, Journal of Bacteriology,
1999: 181, 5855-5859.
42. Rapid diagnosis of acute pyogenic
meningitis by a combined PCR dot-blot
assay, M.Balganesh, M. K. Lalitha
and R. Nathaniel, Molecular and Cellular
Probes (2000) 14, 61-69.
43. Novel Scintillation Proximity
Assay for Measuring Membrane-Associated
Steps of Peptidoglycan Biosynthesis
in Escherchia Coli. B. Chandrakala,
Bertha C. Elias, Upasana Mehra, N.S.
Umapathy, P. Dwarakanath, T.S. Balganesh
and Sunita M deSousa, Antimicrobial
Agents and Chemotherapy, 2001: 45,
768-775
44. Use of variability in the stage-specific
transcription levels of Plasmodium
falciparum in the selection of target
genes. Vidya Prasanna Kumar and Santanu
Datta. Parasitology International
50 (2001) 165-173.
45. Proteins released during high
toxin production in Clostridium difficile.
Kakoli Mukherjee, Sture Karlsson,
Lars G. Burman and Thomas Akerlund.
Microbiology (2002), 148, 2245-2253.
46. Glycine and alanine dehydrogenase
activities are catalyzed by the same
protein in Mycobacterium smegmatis:
upregulation of both activities under
microaerophilic adaptation, Veeraraghavan
Usha, Ramesh Jayaraman, Juan Carlos
Toro, Sven E. Hoffner, and Kaveri
S. Das. Can. J. Microbiol. 48: 7-13
(2002)
47. Mutational analysis of bacteriophage
T4 AsiA: involvement of N- and C-terminal
regions in binding to 70 of Escherichia
coli in vivo, Umender K. Sharma,
P. V. K. Praveen and T. S. Balganesh.
Gene, 295(1):125-134 (2002)
48. Pharmacokinetics-pharmacodynamics
of rifampin in an aerosol infection
model of tuberculosis. R. Jayaram,
S. Gaonkar, Parvinder Kaur, B.L. Suresh,
B.N. Mahesh, R.Jayashree, Vrinda Nandi,
Sowmya Bharat, R.K. Shandil, E.Kantharaj,
V.Balasubramanian. Antimicrob Agents
Chemother. 47(7):2118-2124. (2003)
49. High-Throughput Screen for Inhibitors
of Transglycosylase and/or Transpeptidase
Activities of Escherichia coli Penicillin
Binding Protein 1b, B. Chandrakala,
Radha K. Shandil, Upasana Mehra, Sudha
Ravishankar, Parvinder Kaur, Veeraraghavan
Usha, Bina Joe, and Sunita M. deSousa.
Antimicrobial Agents and Chemotherapy.
48 (1): 30-40 (2004)
50. Drug discovery for tuberculosis: Bottlenecks and path forward. T.S. Balganesh, V. Balasubramanian and S. Anand Kumar. Current Science. 86(1):167-176 (2004).
51. Isoniazid Pharmacokinetics-Pharmacodynamics
in an Aerosol Infection Model of Tuberculosis.
Ramesh Jayaram, Radha. K. Shandil,
Sheshagiri Gaonkar, Parvinder Kaur,
B. L. Suresh, B. N. Mahesh, R. Jayashree,
Vrinda Nandi, Sowmya Bharath, E. Kantharaj,
and V. Balasubramanian. Antimicrobail
Agents and Chemotherapy, 48(8): 2951-2957
(2004)
52. Biochemical characterization of
Plasmodium falciparum hypoxanthine-guanine-xanthine
phosphorybosyltransferase: Role of
histidine residue in substrate selectivity.
Dhiman Sarkar, Indira Ghosh, Santanu
Datta. Molecular & Biochemical Parasitology.
(2004) In press
Patents
1. A New Method for the Diagnosis
of Virulent Bacteria.
2. DNA Probes Specific for Plasmodium
Vivax
3. A Novel Vector to Produce Biologically
Important Peptides
4. A Novel Procedure for the Detection
of Pathogens Using DNA Probes
5. Peptide-Carbohydrate Conjugates
Generating T-Cell Immunity
6.Ganglioside Analogs
7. Virulence-specific Bacterial DNA Sequence
8. Novel Polypeptides
9. A DNA Molecule for Expression of
Bile Salt-Stimulated Lipase (BSSL)
10. A method of identifying Ligands to RNA
Polymerase Sigma 70 subunit
11. A Scintillation Proximity Assay for the
Detection of Peptidoglycan Synthesis
12. New Use.
13. Novel Process
14. Mycobacterial Inhibitors
15. New Assay
16. Assay for Detection of Transferase
Enzyme Activity in Drug Screening
Research papers available on request
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